Ilmuwan Mencetak Sel Testis Manusia 3D

Para ilmuwan di Kanada British Columbia (UBC) menggunakan teknologi 3D untuk mencetak sel-sel testis manusia dan menemukan bahwa mereka memiliki tanda-tanda awal sperma untuk menghasilkan sperma, yang pertama kali di dunia. Tim peneliti Dr. Ryan Flannigan, Asisten Profesor Asisten Urologi UBC, memiliki waktu satu-hari, yang memberikan solusi bagi pasien yang saat ini tidak dapat diobati.

"15 percent of the couple suffer from infertility, at least half of them is caused by male factors." Flannigan said its laboratory established a Vancouver's prostate center in Vancouver General Hospital. We are printing testicular cells into a special structure that imitates the human anatomy with 3D printing technology, which we believe this is the best way to stimulate sperm generation. "Flannigan said, if success, this will open the new birth treatment door for those who have no other choice.

Pada testis manusia, sperma diproduksi oleh tabung kecil yang disebut tabung halus. Pada infertilitas pria yang paling parah-non-penyakit non-sperma (NOA), sperma ditemukan dalam ejakulasi karena pengurangan sperma yang dihasilkan oleh struktur tabung kecil ini. Meskipun dalam beberapa kasus, dokter dapat membantu pasien NOA menemukan sperma yang sangat langka dengan operasi, tetapi Flannigan mengatakan hanya setengah dari tingkat keberhasilan.

"Unfortunately, for the other half of patients, they have no choices, because we can't find sperm for them." Flannigan said, these is the patient who wants to help. In recent studies, researchers conducted biopsy for testis of NOA patients and collected stem cells. These cells were then cultured, and 3D was printed into a hollow tubular structure on the petri dish, similar to the fine elipes capable of producing sperm.

After 12 days, the research team found that these cells did not only survive, but also growing several special cells participating in sperm production, and there was significant improvements in the maintenance of stem cells - this is the early signs of sperm production capacity. The results of this study were recently published in "Plastic and Infertility Science".

"These cells survive and start differentiation, which is a huge milestone. Although there is still a long way to go, this makes our team full of hope." Flannigan said.

The team is currently committed to the "training" cells producing sperm. In order to do this, they exposed cells in different nutrients and growth factors, and fine-tuned their structural arrangements to promote interaction between cells. If these cells can produce sperm, these sperm may pass through in vitro fertilization Make the egg fertilization and provide a new birth treatment option for the couple.

Proyek penelitian juga mengungkapkan mekanisme genetik dan molekuler yang mengarah pada NOA. Tim Flannigan telah menggunakan berbagai teknik pengurutan-sel tunggal untuk memahami ekspresi gen dan karakteristik setiap sel, lalu menghitung model untuk lebih memahami akar penyebab penyakit dan menentukan rencana pengobatan baru. Karya ini juga membutuhkan kerjasama yang tinggi, melibatkan peneliti UBC di bidang ilmu komputer, matematika, dan teknik, serta kerjasama internasional lainnya.

"We are increasingly learned that infertility may have many different reasons, and every case varies from person to person." Flannigan said, "Considering this, we are taking a personalization, precise Medical Methods - Extracting the cells from the patient, trying to understand its unique abnormal conditions, and then supported by 3D printing to overcome these original defects. "